Discovery funnel
Peptide Drug Discovery for Therapeutic Programs
Therapeutic peptide programs require more than candidate generation — they require a structured path from target biology to a development-ready drug candidate. We support pharma and biotech teams building peptide-based therapeutic pipelines, from target identification through preclinical candidate selection.
The Peptide Discovery Challenge
Peptide drug discovery requires navigating a complex design space. The sequence must engage the target with sufficient affinity and selectivity, while also meeting the stability, solubility, and developability requirements for clinical use. These objectives are often in tension.
Traditional discovery approaches — screening large libraries or relying on natural peptide sequences — are increasingly being supplemented by computational methods that can explore the design space more efficiently and prioritize candidates with better development profiles.
Our Discovery Approach
Target analysis
Structural and functional analysis of the target to identify the binding site, key interactions, and design constraints.
AI-assisted candidate generation
Computational methods generate candidate sequences optimized for target engagement and developability simultaneously.
Structure-informed design
Where structural data is available, binding mode prediction and docking analysis guide candidate design.
Experimental feedback integration
Experimental results from early candidates are integrated into subsequent design cycles to improve candidate quality iteratively.
Discovery Workflow
Target submission
Provide your target, available structural data, and discovery objectives.
Target assessment
Analysis of target tractability and design constraints for peptide-based approaches.
Candidate design
Computational generation of candidate sequences optimized for target engagement and developability.
Candidate prioritization
Ranking of candidates by predicted activity, selectivity, and developability.
Experimental development
Priority candidates are advanced to experimental validation.
Development decision
Validated candidates are assessed for progression to lead optimization.
What Can Be Evaluated
What You May Receive
Target assessment report
Analysis of target tractability and design constraints for peptide discovery.
Candidate peptide series
Designed candidate sequences with predicted activity and developability profiles.
Discovery strategy document
Recommended approach for experimental validation and iterative optimization.
Development roadmap
Outline of the path from initial candidates to a developable lead.
Deliverables depend on project scope and target characteristics. Discovery outcomes cannot be guaranteed.
Who This Is For
Academic researchers
Research groups with validated targets seeking peptide-based tool compounds or drug candidates.
Biotech companies
Companies exploring peptide modalities for targets where small molecules or biologics have limitations.
Drug discovery teams
Internal teams needing computational and scientific support for peptide discovery programs.
Frequently Asked Questions
Start a Therapeutic Peptide Discovery Program
Submit your target for an initial assessment. We will evaluate the therapeutic discovery opportunity and outline a potential approach for your pipeline.
Confidential project discussions available under NDA.